Kendra's sermon "Be A Loser" focuses on the importance of parents caring for themselves to effectively guide their children, referencing her upbringing as an example. She emphasizes the significance of humbling oneself before God in prayer and building an intimate relationship with Him. The sermon stresses the work of holiness in individuals and the need to surrender to God's ways for true holiness. Kendra also encourages maintaining faith and diligence in prayer, cautioning against being swayed by mere emotions.