Pastor Josiah Jones delivers a sermon on anxiety and worry based on Matthew 6, part of Jesus' Sermon on the Mount. He outlines five key truths to combat anxiety: track down your anxiety, remember God's promises, understand that worry is useless, seek God's kingdom and surrender yours, and take it one day at a time. Jones emphasizes that while anxious thoughts are inevitable, we shouldn't dwell on them, instead trusting in God's provision and seeking His kingdom first.